Methylation Support for People Who Overreact to Methylfolate
Some patients feel wired, anxious, or headachy on high-dose methylfolate. For them I want the methylation pathway supported with folinic acid instead, which the body converts at its own pace. Methyl-SP is Apex's folinate version: 1,200 mcg DFE of calcium folinate, 600 mcg methylcobalamin, active B6 and B2, 550 mg trimethylglycine, MSM, beet root, and vitamins C and E. Apex designs it to support liver methylation and the transsulfuration of homocysteine.*
Who I Reach For This With
- Homocysteine running high on a lab
- MTHFR variants in someone who didn't tolerate methylfolate
- Fatigue, fog, or mood symptoms with low B12 or folate
- As the methylation piece under a detox program
What Makes This Form Different
Apex makes two. Methyl-SP (this one) uses folinate at 1,200 mcg. Super Methyl-SP steps the folate up to 2,500 mcg. Start with Methyl-SP unless your practitioner wants the higher dose; TMG at 550 mg per serving is the same in both.
How It Fits Into a Protocol
Two capsules two to three times a day with food, 90 days, homocysteine before and after. Runs alongside Metacrin-DX during liver work.
Frequently Asked Questions
Folinate or methylfolate?
Folinate is one step back in the pathway and gentler for people who overreact. If you do fine on methylfolate, either works.
Can I take it with a B-complex?
Watch the totals; this is already a high-potency B6, B2, and B12 source.
Why the 60-day note?
Apex recommends using it within 60 days of opening to keep the B vitamins at full potency.
Suggested Use: Take 2 capsules 2 to 3 times a day, or as directed by your healthcare professional. 90 vegetarian capsules per bottle.
Selected by Dr. Lorn Allison, DN.
Ships direct from Apex Energetics — never third-party or gray-market stock. Apex sells only through licensed practitioners, so every bottle leaves their facility the week it is ordered.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.