A Ready-to-Use Form of Folate
Pure Encapsulations notes that L-5-MTHF does not require activation by DHFR and MTHFR enzymes. It calls Folate 1,000 a "universally metabolized form of folate."*
Who I Reach For This With
- Patients with MTHFR variants
- Methylation, neurotransmitter and DNA-synthesis support protocols
- Patients whose practitioner wants a folate that is gluten free, GMO free and vegan
- Anyone who wants a folate free from magnesium stearate and artificial colors and sweeteners
What Makes This Form Different
- Folate as Metafolin® L-5-MTHF: 1,667 mcg DFE (1,000 mcg L-5-MTHF) per (size 3) vegetarian capsule
- Pure Encapsulations: it “provides all of the benefits of folic acid regardless of MTHFR genetic variations”*
- Available from Pure in 400 mcg and 1,000 mcg; Metafolin is a naturally occurring, universally metabolized form of folate
- Gluten free, GMO free, vegan and vegetarian, and free from wheat, soy, dairy, eggs, artificial colors and sweeteners, and magnesium stearate
What Pure Encapsulations Says It Supports*
- Supports methylation, "which maintains healthy neurotransmission, DNA synthesis and gene regulation"*
- Provides all of the benefits of folic acid regardless of MTHFR genetic variations*
- Supports cardiovascular, cellular and neuronal health*
How It Fits Into a Protocol
Folate pairs with methylcobalamin, so Apex B12 or Thorne B12 is the usual partner, with Magnesium Glycinate (Thorne) for the broader methylation picture. Thorne 5-MTHF is another option for the same 1 mg dose in a different form and count.
Frequently Asked Questions
Is this the same as 5-MTHF?
Yes. Metafolin® is L-5-methyltetrahydrofolate (L-5-MTHF), and Pure Encapsulations also sells it in 400 mcg.
When should I take it?
1 capsule daily with a meal.
Who should check with their provider first?
Anyone who is pregnant or lactating, has a health condition, or takes prescription medication, should check with their prescribing provider before adding this.
Supplement Facts: Serving size 1 capsule. Each (size 3) vegetarian capsule contains: Folate (as Metafolin, L-5-MTHF) 1,667 mcg DFE (1,000 mcg L-5-MTHF). Other ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water). Metafolin is a registered trademark of Merck KGaA, Darmstadt, Germany.
Suggested Use: 1 capsule daily, with a meal or as directed by your healthcare professional. 90 capsules per bottle.
Warnings: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use. Store in a cool, dry place.
Ships direct from Pure Encapsulations — never third-party or gray-market stock. Every bottle comes straight from their facility, so lot numbers and expiration dates are exactly what Pure shipped.
Selected by Dr. Lorn Allison, DN.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
