Lithium (orotate) 5 mg

Offers the essential trace element lithium to support healthy mental function, including mood, emotion, memory and behavior.

  • Supports mood, emotional wellness and behavioral health
  • Supports cognitive function
  • Promotes neurotransmitter activity
  • Combination of lithium and N-acetyl-l-cysteine (NAC)
  • Part of the PureSYNAPSE product line
  • Made with high-quality ingredients backed by verifiable science


  • Ages 18 and up
  • Emotional wellness and mood support

Suggested Use

As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.

Verifiable Science

Lithium is an essential micronutrient with some chemical properties similar to calcium and magnesium. It is present in all organs and tissues in the body's Lithium has a long history of clinical use for supporting healthy mood and behavior, possibly through dopamine- and serotonin-mediated mechanisms.1-3 Lithium supports neurotransmitter systems and signaling cascades involved in brain health and behavior.1,3 Several studies suggest that lithium supports memory and mood.1,4,5 A 12-month, randomized, double-blind trial involving 45 individuals suggests that low-dose lithium supplementation promotes cognitive performance.6 In cultured neurons, lithium-enhanced gene expression of glutathione-S-transferase (GST), a detoxification enzyme with neuroprotective functions.7 Lithium also has been shown to promote healthy brain-derived neurotrophic factor (BDNF) levels in animal models and humans.8‡



  1. SzklarskaD, Rzymski P.Biol Trace Elem Res189,18-27 (2019).
  2. Beaulieu JM, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104.
  3. Schrauzer GN, et al. Biol Trace Elem Res. 1994 Jan;40(1):89-101.
  4. Nunes MA, et al. Curr Alzheimer Res. 2013 Jan;10(1):104-7.
  5. Forlenza OV, et al. Br J Psychiatry. 2011 May;198(5):351-6.
  6. Straten G. Curr Alzheimer Res. 2011 Dec;8(8):853-9.
  7. Shao L, et al. Neuroscience. 2008 Jan 24;151(2):518-24.
  8. Leyhe T, et al. J Alzheimers Dis. 2009;16(3):649-56.
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