Deglycyrrhizinated licorice, DGL, is widely recognized for its role in gut repair because of how it supports the health of the gastrointestinal lining. Here is what it does, in plain language.
1. It helps the lining heal
DGL stimulates mucus production, which protects the stomach lining and creates a barrier against acid and irritants. It also promotes regeneration of the mucus-secreting cells themselves, which is why it has a long history in ulcer care.
2. It calms inflammation
DGL reduces inflammatory mediators such as prostaglandins and cytokines like IL-1 and IL-6. That soothes irritation in the gut lining, which matters in gastritis, ulcers and inflammatory bowel conditions.
3. It works with the body's defenses, not against them
Instead of suppressing stomach acid the way conventional medications do, DGL increases blood flow to damaged tissue and supports the prostaglandin activity that drives repair. You keep your acid, which you need for digestion, and the lining gets stronger.
4. It has activity against H. pylori
DGL has shown activity against Helicobacter pylori, the bacterium linked to ulcers and gastritis, by interfering with its protein synthesis and DNA replication.
5. It eases spasm
DGL relaxes the intestinal wall, reducing cramping and supporting digestive comfort, which further supports healing.
6. It is safe for long-term use
Traditional licorice contains glycyrrhizin, which can raise blood pressure and deplete potassium with regular use. DGL has the glycyrrhizin removed, so those side effects go away and it can be used for the weeks or months a lining repair actually takes.
In summary: DGL helps gut repair by boosting protective mucus, reducing inflammation, supporting tissue regeneration and offering antimicrobial benefits, and it is safe for extended use. It is one of the building blocks in my 3-Phase Digestive Health Protocol.
Reference: Glycyrrhiza glabra (Licorice), PubMed Central, 2020. PMC7348626. Mucosal cell renewal: PMID 7250207.
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