Thorne 5-MTHF 5 mg — repletion-strength active folate
This is the same L-5-methyltetrahydrofolate as Thorne's 1 mg capsule at a higher dose, for the situations where maintenance folate isn't enough, or when your practitioner has set a higher level. Thorne describes it this way: "Support heart health, fetal development, nervous system, and mood with 5-MTHF."*
Who I Reach For This With
- People whose homocysteine hasn't moved on the 1 mg capsule
- People with MTHFR variants, under practitioner supervision. Thorne notes it is "suitable for those with MTHFR gene mutations."*
- Folate repletion when labs show it is needed
- Protocols where your practitioner has set folate at the higher level
What Makes This Form Different
- Folate as L-5-methyltetrahydrofolate, the bioactive, methylated form: 8.3 mg DFE per capsule
- Thorne: "a bioactive, methylated form of folate"*
- Gluten free, dairy free and soy free, in a cellulose capsule
What Thorne Says It Supports*
- Heart health*
- Nervous system function*
- Mood support*
- Brain, blood, and bone health*
- Fetal development*
How It Fits Into a Protocol
Run it with methyl-B12. High-dose folate without B12 can mask low B12, so the two belong together. Thorne Vitamin B12 1 mg is the natural partner. Once labs settle, step down to the 1 mg capsule. Retest in 8 to 12 weeks, or as your practitioner directs.
Frequently Asked Questions
Do I need a practitioner for this dose?
Yes. This is a higher-dose folate, so use it as directed and have labs rechecked on the schedule your practitioner sets.
Any side effects?
Some sensitive people feel restless or irritable. Take it in the morning, and let me know if you do so we can adjust.
Who should check with their prescriber first?
Anyone who is pregnant, per Thorne's label, and anyone taking methotrexate. Check with your prescribing provider before adding this.
Supplement Facts: Serving size 1 capsule, 60 servings per container. Folate (as L-5-Methyltetrahydrofolate) 8.3 mg DFE. Other ingredients: leucine, microcrystalline cellulose, silicon dioxide, hypromellose (derived from cellulose) capsule.
Suggested Use: Take 1 capsule one to two times daily or as recommended by your health-care practitioner. 60 capsules per bottle.
Warnings: Contraindicated in anyone with a history of hypersensitivity to any of its ingredients. If pregnant, consult your health-care practitioner before using this product.
Ships direct from Thorne's own facility — never third-party or gray-market stock. Lot numbers and expiration dates are exactly what Thorne shipped.
Selected by Dr. Lorn Allison, DN.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
