Thorne 5-MTHF 1 mg — the active folate that skips the MTHFR bottleneck
Folic acid has to be converted four times before the body can use it, and roughly 60% of adults carry an MTHFR variant that slows the last step. 5-MTHF is the finished, active form — it goes straight into the methylation cycle that runs neurotransmitter production, homocysteine clearance, DNA repair and detoxification.
Who I reach for it with: anyone with a known MTHFR variant; elevated homocysteine; mood and energy protocols where methylation is the lever; pre-conception and pregnancy support; people who felt worse on folic acid.
What makes it different: 1 mg (1,700 mcg DFE) of L-5-methyltetrahydrofolate, nothing else in the capsule but cellulose, leucine and silica. Thorne's purity testing. Also available in 5 mg for high-dose repletion.
Protocol fit: pairs with methyl-B12 and Magnesium Glycinate in methylation protocols; Thorne Basic B is the multi-B partner. Pure Encapsulations Folate 1,000 is the equivalent 1 mg dose as Metafolin.
FAQ — 1 mg or 5 mg? 1 mg is the everyday maintenance dose; 5 mg is for practitioner-directed repletion or high homocysteine.
FAQ — Can methylfolate make me anxious? A small number of people feel wired at higher doses — start at 1 mg and take it in the morning.
Supplement Facts: Serving size 1 capsule, 60 servings. Folate (as L-5-Methyltetrahydrofolate) 1.7 mg DFE (1 mg). Other ingredients: hypromellose capsule, leucine, microcrystalline cellulose, silicon dioxide.
Suggested Use: Take 1 capsule daily, or as directed by your healthcare professional.
Flat $11.99 shipping, free over $250.
Selected by Dr. Lorn Allison, DN.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
