Thorne 5-MTHF 1 mg — the Bioactive, Methylated Form of Folate
Folate comes in several forms, and the body has to convert some of them before it can use them. 5-MTHF is the bioactive, methylated form. Thorne describes it this way: "Support heart health, fetal development, nervous system, and mood with 5-MTHF."*
Who I Reach For This With
- People with a known MTHFR variant
- People whose homocysteine or methylation labs have me looking at folate status
- Mood and energy protocols where methylation is part of the plan
- Preconception and pregnancy planning
- People who prefer a methylated folate over folic acid
What Makes This Form Different
- 1.7 mg DFE of folate per capsule, as L-5-methyltetrahydrofolate (1 mg), with only leucine, microcrystalline cellulose, silicon dioxide and a hypromellose capsule
- Thorne: "5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brain, blood, and bone health."*
- Thorne: "suitable for individuals with MTHFR gene mutations."* Thorne also makes a 5 mg version, and lists this product as gluten free, dairy free and soy free
What Thorne Says It Supports*
- Heart health*
- Fetal development*
- Nervous system function*
- Mood support*
- Heart, brain, blood, and bone health*
How It Fits Into a Protocol
5-MTHF pairs with methyl B12 and Magnesium Glycinate in methylation-focused protocols, and Thorne Basic B is the multi-B partner. Pure Encapsulations Folate 1,000 is a similar-dose alternative.
Frequently Asked Questions
1 mg or 5 mg?
1 mg is the everyday strength. Thorne also makes a 5 mg capsule, and which strength you use is a practitioner decision.
Can methylfolate make me feel wired?
Some people prefer to take it earlier in the day. If you notice you feel off on it, tell your practitioner.
How often do I take it?
Thorne's label says 1 capsule one to three times daily, or as your practitioner recommends.
Supplement Facts: Serving size 1 capsule, 60 servings. Folate (as L-5-Methyltetrahydrofolate) 1.7 mg DFE (1 mg). Other ingredients: leucine, microcrystalline cellulose, silicon dioxide, hypromellose capsule.
Suggested Use: Take 1 capsule one to three times daily, or as directed by your healthcare professional. 60 capsules per bottle.
Warnings: If pregnant, consult your health-care practitioner before using this product. If you take any prescription medication, check with your prescribing provider before adding this. Thorne's label also notes this product is contraindicated for anyone with a history of hypersensitivity to any of its ingredients.
Ships direct from Thorne's own facility — never third-party or gray-market stock. Lot numbers and expiration dates are exactly what Thorne shipped.
Selected by Dr. Lorn Allison, DN.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
