Thorne 5-MTHF 5 mg — repletion-strength active folate
This is the same L-5-methyltetrahydrofolate as Thorne's 1 mg capsule at five times the dose, for the situations where maintenance folate isn't enough: stubborn homocysteine, documented folate deficiency, or a protocol your practitioner has set at the higher level.
Who I reach for it with: elevated homocysteine that hasn't responded to 1 mg; homozygous MTHFR variants under supervision; mood protocols where the literature used 5–15 mg; folate repletion on labs.
What makes it different: 8,500 mcg DFE in a clean capsule — no folic acid, no fillers beyond cellulose and leucine. Thorne's testing.
Protocol fit: run it with methyl-B12 — high-dose folate without B12 can mask a B12 deficiency. Step down to the 1 mg capsule once labs normalize.
FAQ — Do I need a practitioner for this dose? Yes — 5 mg is a therapeutic dose. Use it as directed and retest homocysteine in 8–12 weeks.
FAQ — Any side effects? Restlessness or irritability in sensitive people; take it in the morning and reduce if needed.
Supplement Facts: Serving size 1 capsule, 60 servings. Folate (as L-5-Methyltetrahydrofolate) 8.3 mg DFE (5 mg). Other ingredients: hypromellose capsule, leucine, microcrystalline cellulose, silicon dioxide.
Suggested Use: Take 1 capsule daily, or as directed by your healthcare professional.
Available on Subscribe & Save — 10% off, ships automatically every 1, 2 or 3 months. Flat $11.99 shipping, free over $250.
Selected by Dr. Lorn Allison, DN.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
